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ED CurrentsEating Disorder Science · Farther Shore Institute
Eating disorder science · education · care

Move with the current.
Hope is evidence-based.

Eating disorders are serious, treatable, and finally getting the science they deserve. ED Currents gathers that momentum into one bright, open place — the research index, the guidelines, the care map, free education, and the interventional frontier — for clinicians, researchers, and families alike.

1 in 10people will experience an eating disorder — every body, every background
Full recoveryis possible from every eating disorder diagnosis
Freeeducation, tools, and screening resources — our way of giving back
What lives here

One harbor, every ship

The Research Library

Ketamine & psychedelics in eating disorders

Two separate collections, for two separate needs: published evidence you can read and cite, and trials in progress you can follow or refer to — from the first ketamine infusions in 19981 to studies now enrolling.2

Published Evidence

What the literature actually shows

The published literature on ketamine, psilocybin, MDMA, and ayahuasca in eating disorders — feasibility trials, case series, secondary analyses, qualitative work, and the reviews that synthesize them. A field still early in its evidence (no completed phase-3 RCT yet exists), which is exactly why seeing all of it in one place matters. Each entry links to its primary source; this is what you cite, not treatment advice, and inclusion is not endorsement of efficacy.

Trials in Progress

What's being studied right now

Recruiting, active, and planned studies — research that hasn't reported results yet. For patients and families, these may be avenues to care; for clinicians and researchers, a map of where the field is heading. Verify current enrollment status directly, since it changes often.

Looking for a trial to join? Search live registries for the most current listings: ketamine × EDs · psilocybin × EDs on ClinicalTrials.gov. Talk with your treatment team before enrolling — trial participation carries real risks, especially in a medically vulnerable population.
How this library works. A curated, verified collection (v2.0, July 2026) maintained by ED Currents.6 Every published entry links to its primary source; every trial links to its registry record. The safety literature at this intersection3 is required reading before any clinical application. Spot an error or a missing study? Submit a correction or study.
Key References

Landmark sources in this field

The studies that anchor this library. Every card above also links directly to its own primary source.

    Guidelines Library

    Every published standard, one shelf

    The major clinical practice guidelines for eating disorder care, tagged by audience. Clinicians: these define the standard of care. Families: knowing they exist is power — a program should be able to tell you how its care maps to them.

    Treatment Directory

    Find care, understand the levels

    A directory of established eating disorder treatment programs across levels of care. Listings are informational — not endorsements, referrals, or guarantees. Always verify licensure, accreditation, insurance, and current availability directly.

    Levels of care, in plain language

    Where does treatment happen?

    Medical stabilization & inpatient

    Hospital-based care for when the body is in danger — severe malnutrition, unstable vitals, electrolyte disturbance. Medicine first; everything else follows.

    Residential

    24-hour therapeutic care in a non-hospital setting, for those who are medically stable but need round-the-clock support with meals, urges, and structure.

    PHP & IOP

    Partial hospitalization (typically full weekdays) and intensive outpatient (several sessions weekly) — structured treatment while living at home.

    Outpatient & virtual

    A therapist, dietitian, and medical provider working as a team — increasingly available virtually, including family-based treatment (FBT) delivered at home.

    Directory standards. Seed listings (v1.0) include established, accredited programs; a structured submission and verification process is coming. Programs: request a listing. No program pays to appear here, and payment will never influence inclusion or order.
    Community & Events

    The ecosystem that holds the field

    No one recovers alone, and no one researches alone. These are the professional societies, family organizations, and gatherings that make up the eating disorder community.

    Get help now

    Helplines

    988 Suicide & Crisis Lifeline24/7 crisis support by call or textCall or text 988
    National Alliance for Eating DisordersWeekday helpline answered by licensed clinicians1-866-662-1235
    ANAD HelplinePeer support for eating disorders1-888-375-7767
    Professional

    Societies & professional bodies

    Advocacy & family

    Nonprofits, advocates, and family organizations

    Gatherings

    Conferences & events

    On retreats. We are frequently asked about psychedelic retreats for eating disorder recovery. We will only list programs that are lawful in their jurisdiction, clinically screened, and transparent about medical oversight — because eating disorders carry specific physiological risks (cardiac, electrolyte, and otherwise) that make unscreened psychedelic use genuinely dangerous. A vetted listing standard is in development; until then, discuss any retreat with a physician who knows your history.
    Currents

    News in the science, the advocacy, the care

    What's moving in the field — trial results, policy, and milestones — curated with a clinician's eye for what actually matters.

    Join Currents

    A concise digest of eating disorder science, advocacy, and care — for clinicians, researchers, and families. Signal, not noise. Unsubscribe anytime.

    Learn

    Education for families and clinicians

    Plain-language foundations, the honest state of the interventional frontier, and the safety standards this new era requires.

    What eating disorders are

    Eating disorders — anorexia nervosa, bulimia nervosa, binge eating disorder, ARFID, and others — are serious, biologically-influenced illnesses, not choices, phases, or vanity. They affect people of every gender, age, body size, race, and income. They are also treatable, and outcomes improve dramatically with early, evidence-based care. Person-first language matters: people live with eating disorders; they are never defined by them.

    Why the interventional frontier?

    Anorexia nervosa still has no FDA-approved medication, and relapse after standard treatment remains common. Interventional psychiatry — ketamine, psilocybin, and related medicines paired with structured therapy — targets the cognitive rigidity, depression, and suicidality that keep severe illness entrenched. The early evidence is promising and honest: small studies, encouraging signals, much still to prove. That is exactly why rigorous science, not hype, must lead.

    Safety Standards · The signature commitment of this project

    Interventional treatments meet a medically vulnerable population

    People with eating disorders can carry physiological vulnerabilities that most psychedelic and ketamine research populations do not. Any clinician, researcher, or program working at this intersection should address, at minimum:

    • Cardiac status — including ECG screening and QTc review, given the cardiac effects of malnutrition and the physiologic effects of these medicines.
    • Electrolytes & hydration — especially with purging behaviors, and re-checked close to any dosing day.
    • Nutritional and refeeding status — medical stability must precede interventional treatment, never substitute for it.
    • Blood pressure and medication interactions — reviewed against the person's full regimen.
    • Integration with ED-specialist care — these treatments are adjuncts to comprehensive eating disorder treatment, not replacements for it.

    Grounded in the peer-reviewed safety literature (see Downey et al., Journal of Eating Disorders, 2024, in the Research Index). Educational only — not medical advice. A full published safety standard is in development with clinical reviewers.

    Ten questions to ask any treatment program

    1. Which levels of care do you offer, and how do you decide when someone steps up or down?
    2. How does your care map to published guidelines (APA, NICE, MEED)?
    3. Who is on the treatment team — and how often does each discipline actually see my person?
    4. How do you involve families, and do you offer family-based treatment?
    5. What are your medical monitoring protocols — labs, vitals, ECG?
    6. How do you treat co-occurring conditions like depression, anxiety, OCD, and trauma?
    7. What does a typical day look like, meal by meal?
    8. How do you measure outcomes, and what will you share with us?
    9. What does discharge planning and relapse prevention look like from day one?
    10. What will this cost, what does insurance cover, and who helps us navigate that?

    Glossary of the frontier

    Ketamine-assisted psychotherapy (KAP)
    Sub-anesthetic ketamine paired with structured psychotherapy, using the window of enhanced neuroplasticity for therapeutic work.
    Psilocybin-assisted therapy
    A supervised psilocybin session embedded in preparation and integration therapy; investigational for eating disorders.
    Cognitive rigidity
    The inflexible thought patterns characteristic of anorexia nervosa — a key target of interventional treatments.
    SE-AN
    Severe and enduring anorexia nervosa — long-standing illness that has not remitted with standard treatment.
    FBT
    Family-based treatment — the leading evidence-based approach for adolescents, empowering parents to lead renourishment.
    Expanded access
    Regulated pathways to investigational treatments outside clinical trials for people with serious conditions.
    Screening tools. Validated instruments like the EDE-Q, EAT-26, and SCOFF can support — never replace — professional assessment. A curated screening-tools page with clinician scoring guides is in development. If you're concerned about yourself or someone you love, a conversation with a professional is the right first step, and the helplines under Community can help you find one.
    The Medical Care Academy · Free Education

    Learn to see it. Learn to treat it.

    An interactive learning experience in the medical care of eating disorders — built for clinicians of every specialty, trainees, and the families who so often see it first. Free, forever. This is our way of giving back.

    1 in 10
    people will experience an eating disorder in their lifetime1
    Among
    the highest
    anorexia's mortality rank of any psychiatric illness — often cited as second only to substance use disorders2
    ~1 in 5
    anorexia deaths are by suicide — screen for risk, always3
    Recovery
    is possible from every eating disorder diagnosis, at any stage4
    Start here

    Most eating disorders are invisible.

    The majority of people living with one are not underweight. Serious medical danger occurs at every body size — and the exam and labs can look completely normal. Learning to see past the stereotype is the single most life-saving skill in this whole course.

    Explore the warning signs ↓
    The golden rule of this entire field

    A life-threatening eating disorder can be present with no obvious physical signs and completely normal laboratory results. Suspicion, history, and behavior outrank any single test. When in doubt, screen and refer — never wait for the labs to declare an emergency.

    Is anorexia the #1 or #2 deadliest psychiatric illness? The honest answer →

    You'll see both claims, often stated with equal confidence. Here's the scientifically defensible version. The landmark meta-analysis by Arcelus and colleagues (2011) found anorexia nervosa carries an all-cause standardized mortality ratio of about 5.86 — patients are nearly six times as likely to die as age-matched peers — and it is frequently described as having the highest mortality rate among the classic psychiatric diagnostic categories.2

    However, the most comprehensive meta-review to date (Chesney, Goodwin & Fazel, 2014; over 1.7 million patients) estimated that several substance use disorders — opioid, cocaine, and amphetamine use — carry mortality risks higher than anorexia nervosa.5 This is why careful clinical sources describe anorexia as the second-most-lethal psychiatric disorder, surpassed only by substance use disorders.6

    The defensible bottom line: anorexia nervosa has one of the highest mortality rates of any psychiatric illness — commonly ranked second only to substance use disorders. The exact rank depends on how substance use disorders are grouped and measured. What is not in dispute: eating disorders are among the deadliest mental illnesses, and roughly half of those deaths trace to medical complications and half to suicide.3

    The path

    Six modules, one patient journey

    1
    Essentialsthe truths
    2
    Recognizethe signs
    3
    Assessworkup
    4
    Treatrefeeding
    5
    Specialtiespearls
    6
    Actintervene
    Source & credit. This academy is an independent educational companion inspired by and drawing on Eating Disorders: A Guide to Medical Care (4th edition, 2021), created by the Academy for Eating Disorders' Medical Care Standards Committee — the field's beloved "purple book." We summarize its clinical wisdom in our own words, with admiration. Download the original free, in many languages, at aedweb.org. Educational only — not medical advice, and not a substitute for clinical judgment or the original guide.
    Module 01 · The Essentials

    Six truths — now check yourself

    You've seen the shape of it above. Now lock it in: myth or fact? (Answer, then reveal the reasoning.)

    Module 02 · Recognize

    The red-flag explorer

    Physical signs cluster by body system — but remember the golden rule: a life-threatening eating disorder can be present with no obvious physical signs and completely normal labs. Tap a system to review its warning signs:

    Module 03 · Assess

    The workup — and when to hospitalize

    History highlights: the rate and amount of weight change matters as much as absolute weight — rapid loss at any starting weight can produce the same complications as severe underweight. Ask about weight suppression (highest recent weight minus current; even ~5% can be medically significant), compensatory behaviors, exercise rigidity, menstrual changes, and psychiatric history including suicidality.

    Baseline testing for every suspected ED: CBC, comprehensive metabolic panel, and ECG. Patterns worth knowing: low potassium and chloride with raised bicarbonate suggest vomiting; low phosphate flags early refeeding risk; mildly elevated transaminases occur in starvation; ECG may show bradycardia or QTc prolongation above 450 ms. And again — normal results never rule out a dangerous eating disorder.

    Interactive: hospitalization triggers. Check any that apply to a (hypothetical) patient — adapted from published admission criteria for medical and psychiatric stabilization:

    One or more admission criteria present → urgent evaluation for hospital-level stabilization is indicated. Loop in an eating disorder specialist early.
    Module 04 · Treat

    Refeeding: the rescue that must be done right

    Refeeding syndrome — the metabolic derangement that can follow renourishment of a malnourished patient — can cause edema, cardiac and respiratory failure, delirium, and death. Its laboratory hallmark is hypophosphatemia, with hypoglycemia, hypokalemia, and hypomagnesemia close behind. Electrolytes typically reach their lowest point 3–7 days after feeding begins, so check before starting and monitor daily early on. Give a multivitamin, consider thiamine in severe malnutrition, replete electrolytes without delaying feeding, and rehydrate gently — low-rate continuous fluids, not boluses.

    The old reflex of "start low, go slow" has been overturned: underfeeding is its own danger, prolonging illness and worsening prognosis. Current evidence supports higher-calorie starts (roughly 1600–2400 kcal/day) with stepwise increases every 1–3 days under close lab monitoring — and many patients ultimately need 3500–4000 kcal/day or more for consistent restoration. Oral nutrition is always preferred.

    Interactive: refeeding risk screen. Any single factor argues for inpatient initiation with specialist support:

    Refeeding risk present → consider initiating nutrition in an inpatient setting with ED-specialist support and daily electrolyte monitoring.
    Module 05 · Every Specialty Sees It First

    Pearls by discipline

    People with eating disorders arrive everywhere before they arrive at an ED program — the dentist's chair, the ER, the cardiology clinic. One pearl can change a trajectory:

    Module 06 · Act

    Five timely interventions

    1 — Expect ambivalence; it's a symptom. Minimizing and hiding are part of the illness, and articulate competence elsewhere can mask severity. 2 — Trust the family's worry. Parents and partners are the frontline help-seekers; even a single consultation about eating or weight concerns strongly predicts a real problem. 3 — Diffuse blame. Families didn't cause it; patients didn't choose it — saying so out loud opens the door to treatment. 4 — Monitor the body. Regular vitals and labs, interpreted in the context of starvation physiology, remembering everything can look normal. 5 — Assess psychiatric risk, always. Up to half of eating disorder deaths are by suicide.

    Toolkit

    Clinical calculators

    Assessment aids for clinicians and caregivers. These contextualize risk — they are never targets, and never a diagnosis.

    QTc calculator

    Corrected QT — flag >450 ms (an admission-criteria threshold; many use >460–470 ms in females)

    Weight suppression

    Highest recent weight − current weight; ≥5% of highest can be medically significant

    Orthostatic vitals

    Lying → standing change; sustained HR rise ≥30 bpm (≥40 in adolescents) or BP drop ≥20/10 mmHg is significant

    Screen in 60 seconds

    The five-question SCOFF is the fastest validated first-pass screen

    Two or more positive answers indicates a possible eating disorder and should prompt referral for full evaluation. Take it interactively on our Scales page.

    Go to the SCOFF →
    References & Sources

    Every claim, cited

    This is a science site; our numbers should be checkable. Key statistics on this page trace to the peer-reviewed sources below. Where the literature is genuinely mixed, we say so rather than pick the more dramatic number.

      Validated Rating Scales

      Measurement, honestly used

      Self-report measures used in eating disorder research and care. A screen is a doorway, never a diagnosis — a positive result means "worth a real conversation with a professional," and a negative result never overrules concern.

      Take a screening

      Choose a validated self-report screen to complete right here. Everything runs privately in your browser — nothing is saved or sent. A screen is a doorway, never a diagnosis.

      The full scales library

      Widely used, validated instruments — what each measures and where to find the official copyrighted version when it isn't ours to reproduce.

      A word on screening yourself. If a result here lands close to home, that's information worth honoring — not a verdict, and not something to face alone. A clinician, therapist, or dietitian who knows eating disorders can help you make sense of it, and the helplines under Community are staffed by people who do this every day.
      Intuitive Eating

      Making peace with food

      Intuitive Eating is the evidence-based framework created by dietitians Evelyn Tribole and Elyse Resch in 1995 — a compassionate alternative to diet culture, now supported by hundreds of studies linking it to lower disordered eating and better wellbeing.

      What it is

      Intuitive Eating teaches people to rebuild trust with their body — using internal cues of hunger, fullness, and satisfaction, rather than external rules, to guide when, what, and how much to eat. It explicitly rejects the diet mentality and weight stigma, and it has a serious research base: prospective studies find that people who eat more intuitively show lower odds of developing disordered eating, better body image, and greater psychological wellbeing over time. Explore the official home of the framework — including books, research, and a directory of certified counselors — at intuitiveeating.org.

      The ten principles

      Reject the Diet Mentality

      Let go of the promise that the next diet will finally work — the evidence says it won't, and the chase causes harm.

      Honor Your Hunger

      Feed your body adequately and on time; biological deprivation is the fuel of loss-of-control eating.

      Make Peace with Food

      Unconditional permission to eat ends the deprivation-rebellion cycle that forbidden foods create.

      Challenge the Food Police

      Notice and answer the inner rules that score foods as "good" and "bad" and you as good or bad for eating them.

      Discover the Satisfaction Factor

      Pleasure belongs in eating; satisfying meals quiet the search for "more."

      Feel Your Fullness

      Listen for the body's signals of comfortable fullness — trust builds with practice.

      Cope with Your Emotions with Kindness

      Food can comfort, but it can't resolve feelings; build a wider toolbox for hard moments.

      Respect Your Body

      Accept your genetic blueprint and treat your body with dignity at every size.

      Movement — Feel the Difference

      Shift exercise from punishment and calorie math to energy, strength, and how it feels.

      Honor Your Health — Gentle Nutrition

      Food choices that honor health and taste, without perfection; patterns matter, not single meals.

      The Intuitive Eating Scale

      IES-3 — the current version

      The Intuitive Eating Scale-3 (Tylka et al., 2024, Appetite) is a 12-item measure of intuitive eating across four domains: Unconditional Permission to Eat, Reliance on Hunger and Satiety Cues, Eating for Physical Rather than Emotional Reasons, and Body-Food Choice Congruence. It's psychometrically strong, invariant across gender, unbiased across age and BMI — and free to use in any setting.

      Read the development paper (PubMed) →

      Lineage & use

      The IES line began with Tylka's original 2006 scale and the widely used 23-item IES-2 (2013); an early-adolescent adaptation (IES-2-EA) also exists. Researchers and clinicians use these to measure adaptive eating — a reminder that recovery science can measure what's going right, not only what's wrong.

      Official Intuitive Eating resources →
      A clinical nuance worth knowing. In active malnutrition, hunger and fullness signals are physiologically disrupted — so in early eating disorder treatment, structured, supported eating usually comes first, with intuitive eating principles woven in as recovery stabilizes. Intuitive Eating and eating disorder treatment are allies on one timeline, not competitors. Your treatment team can help sequence them.
      A History of Hunger

      The refusing body has always meant something.

      Self-starvation is not a modern invention. Across two thousand years, the behavior recurs — while the meaning a culture assigns to it keeps changing: holiness, hysteria, vanity, illness. Walk the river of that story, and watch the meaning shift beneath your feet.

      Antiquity
      Greece & Rome
      c. 300 BCE

      Hunger before it had a name

      Deliberate self-starvation appears in the Hellenistic world and beyond — ascetics, philosophers, and the practice the Romans knew as inedia. Fasting is woven into ritual and self-mastery long before any physician thinks to call refusal of food a disease. The behavior is old; the diagnosis is young.

      Holy Anorexia
      Medieval Italy · Siena
      1347–1380

      To starve was to touch the divine

      In the Middle Ages, a refusing body could be read as a holy one. Historian Rudolph Bell, studying 170 Italian holy women in Holy Anorexia (1985), found that roughly half showed patterns of extreme self-starvation.1 Catherine of Siena — who by her twenties reportedly lived on almost nothing — became its most famous figure. The Church called it anorexia mirabilis: miraculous loss of appetite.

      Replace the word "thin" with the word "holy," and the behavior looks strikingly familiar.

      Bell's controversial thesis: for women stripped of agency, the mastery of appetite was one of the few forms of autonomy a suffocating society left available. Caroline Walker Bynum's Holy Feast and Holy Fast (1987) offered a richer, competing reading — that food, for these women, was above all about union with a suffering Christ.2

      First Medicine
      London
      1689

      The first doctor to look and worry

      The English physician Richard Morton published the first medical description of what we would now recognize as anorexia nervosa — in his treatise on "consumptions," he called it a nervous atrophy, a wasting born of "sadness and anxious cares" rather than any disease of the lungs. Of one young patient he wrote that he beheld "a skeleton only clad with skin."3 The meaning had begun to shift: from miracle toward malady.

      A Name at Last
      London & Paris
      1873

      Two nations, one discovery, a new name

      In the same year, independently, two physicians described the illness in clinical detail. In Paris, Charles Lasègue wrote of l'anorexie hystérique. In London, Sir William Gull — a physician to Queen Victoria — gave the condition the name we still use: anorexia nervosa. Gull was among the first to insist its roots were of the mind, not the stomach.4 The refusing body was now, officially, a patient.

      The Victorian label hysterica — later dropped — reveals the era's lens: this was read as an affliction of young women's nerves and will.

      The Modern Era
      The West
      1960s–1994

      The century that made it visible

      As the cultural ideal of the female body thinned — the "Twiggy" era — recognition surged. In 1979, British psychiatrist Gerald Russell named bulimia nervosa, "an ominous variant of anorexia nervosa."5 In 1980, the DSM-III created a dedicated Eating Disorders section;6 by 1987 bulimia gained its "nervosa." 1983: the death of Karen Carpenter brought anorexia into millions of living rooms. By 1994, binge eating disorder entered the manual's appendix as a condition for further study.

      Today
      Global
      2013 → now

      Brain, biology, and a wider frame

      The DSM-5 (2013) recognized binge eating disorder as its own diagnosis and added ARFID, decoupling some eating disorders from body image entirely. The science moved toward genetics, neurobiology, and the understanding that these are serious brain-based illnesses affecting every body, gender, and culture — not choices, not vanity. And a new frontier of interventional treatment began to open. The meaning shifts again: from moral failing toward treatable illness — and toward hope.

      The behavior is ancient. Our compassion, and our science, are finally trying to catch up.

      Why history belongs on a science site

      Seeing that self-starvation has worn so many masks — saint, hysteric, fashion victim, patient — is itself a form of treatment. It loosens shame ("this is not your moral failing"), it humbles certainty ("today's explanation is also of its moment"), and it points forward: if the meaning has always been changing, then a kinder, truer understanding is still ours to build.

      Continue to the Medical Care Academy →

      Sources & further reading. Every marker above links to its source below. This is an educational overview; historical "retro-diagnosis" is debated among scholars, and we present it as interpretation, not settled fact.
        About

        A commons, kept honestly

        ED Currents is a project of Farther Shore Institute, an independent nonprofit forming in Utah that funds mental health research and access to care.

        Why we built this

        The eating disorder field is entering its most scientifically interesting decade — real momentum in interventional treatments, real datasets waking up, real policy movement. But the knowledge is scattered across journals, registries, and organizational silos. Families can't find it; clinicians can't track it. This site gathers it into one open harbor, free, for everyone.

        How we stay honest

        No program, company, or sponsor pays for placement, and none ever will. We describe evidence at its actual strength — case series are called case series. Listings are informational, not endorsements. Content is clinician-curated and correctable: if we've erred, tell us and we'll fix it, visibly.

        For researchers

        A generation of large real-world clinical datasets in eating disorders is ready to be studied. Farther Shore Institute funds postdoctoral fellowships and data-driven eating disorder research — and welcomes collaboration inquiries from investigators and institutions. Start a conversation.

        What's next

        A verified directory submission process, a published safety standard for interventional ED care, a screening-tools library, an annual State of the Science review, and vetted event and retreat listings. Want to help shape it? Join Currents — that's where we'll ask.

        Disclaimer. This site provides educational information only and is not medical, psychological, or legal advice; it does not create a treatment relationship. If you or someone you love may have an eating disorder, please consult qualified professionals. In an emergency, call 988 or your local emergency number. Farther Shore Institute 501(c)(3) status pending.